State Police said the crash has all I-87 southbound lanes closed from Exit 21 in Catskill to Ulster County in Saugerties Exit 20 for at least the next six hours.
State police said the crash occurred in Ulster County around 3:50 a.m. Monday, Oct. 28, near mile marker 105.
No one was injured, but an unknown quantity of diesel fuel spilled and is in the process of being cleaned up.
The southbound lanes will be closed most of the morning until the cleanup is complete, state police said.
Drivers are asked to detour at Route 23 to avoid the closure.
This is a developing story. Check back to Daily Voice for updates.
Click here to follow Daily Voice Saratoga Springs and receive free news updates.